Selected Publications

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Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.
Feldcamp L, Doucet JS, Pawling J, Fadel MP, Fletcher PJ, Maunder R, Dennis JW, Wong AH.
Behav Brain Res. 2016 Jun 18;312:253-264. doi: 10.1016/j.bbr.2016.06.033. [Epub ahead of print]
PMID:27329152

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, et al.
Nat Cell Biol. 2016 Jul;18(7):803-13. doi: 10.1038/ncb3376. Epub 2016 Jun 20.
PMID:27323329 | PMCID:PMC4936519

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.
Ryczko MC, Pawling J, Chen R, Abdel Rahman AM, Yau K, Copeland JK, Zhang C, Surendra A, Guttman DS, Figeys D, Dennis JW.
Sci Rep. 2016 Mar 14;6:23043. doi: 10.1038/srep23043.
PMID:26972830 | PMCID:PMC4789752

Many Light Touches Convey the Message.
Dennis JW.
Trends Biochem Sci. 2015 Nov;40(11):673-86. doi: 10.1016/j.tibs.2015.08.010. Epub 2015 Oct 1. Review.
PMID:26439532

The galectin lattice at a glance.
Nabi IR, Shankar J, Dennis JW.
J Cell Sci. 2015 Jul 1;128(13):2213-9. doi: 10.1242/jcs.151159. Epub 2015 Jun 19. Review.
PMID:26092931

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.
Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.
PMID:25852190

Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism.
Abdel Rahman AM, Ryczko M, Nakano M, Pawling J, Rodrigues T, Johswich A, Taniguchi N, Dennis JW.
Glycobiology. 2015 Feb;25(2):225-40. doi: 10.1093/glycob/cwu105. Epub 2014 Oct 1.
PMID:25395405 | PMCID:PMC4276413

Targeted metabolomics in cultured cells and tissues by mass spectrometry: method development and validation.
Abdel Rahman AM, Pawling J, Ryczko M, Caudy AA, Dennis JW.
Anal Chim Acta. 2014 Oct 3;845:53-61. doi: 10.1016/j.aca.2014.06.012. Epub 2014 Jun 12.
PMID:25201272

A novel role for Plk4 in regulating cell spreading and motility.
Rosario CO, Kazazian K, Zih FS, Brashavitskaya O, Haffani Y, Xu RS, George A, Dennis JW, Swallow CJ.
Oncogene. 2015 Jun;34(26):3441-51. doi: 10.1038/onc.2014.275. Epub 2014 Sep 1.
PMID:25174401

N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway.
Johswich A, Longuet C, Pawling J, Abdel Rahman A, Ryczko M, Drucker DJ, Dennis JW.
J Biol Chem. 2014 Jun 6;289(23):15927-41. doi: 10.1074/jbc.M114.563734. Epub 2014 Apr 17.
PMID:24742675 | PMCID:PMC4047366

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.
Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.
Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].
PMID:24550542 | PMCID:PMC4260967

Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution.
Williams R, Ma X, Schott RK, Mohammad N, Ho CY, Li CF, Chang BS, Demetriou M, Dennis JW.
PLoS One. 2014;9(1):e86088. doi: 10.1371/journal.pone.0086088.
PMID:24475074 | PMCID:PMC3901687

Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry.
Abdel Rahman AM, Ryczko M, Pawling J, Dennis JW.
ACS Chem Biol. 2013 Sep 20;8(9):2053-62. doi: 10.1021/cb4004173. Epub 2013 Jul 22.
PMID:23875632

Temporal regulation of EGF signalling networks by the scaffold protein Shc1.
Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T.
Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308.
PMID:23846654 | PMCID:PMC4931914

Density-dependent lectin-glycan interactions as a paradigm for conditional regulation by posttranslational modifications.
Dennis JW, Brewer CF.
Mol Cell Proteomics. 2013 Apr;12(4):913-20. doi: 10.1074/mcp.R112.026989. Epub 2013 Feb 1.
PMID:23378517 | PMCID:PMC3617338

Suppression of cancer progression by MGAT1 shRNA knockdown.
Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW.
PLoS One. 2012;7(9):e43721. doi: 10.1371/journal.pone.0043721. Epub 2012 Sep 5.
PMID:22957033 | PMCID:PMC3434202

Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells.
Boscher C, Zheng YZ, Lakshminarayan R, Johannes L, Dennis JW, Foster LJ, Nabi IR.
J Biol Chem. 2012 Sep 21;287(39):32940-52. Epub 2012 Jul 30.
PMID:22846995 | PMCID:PMC3463368

High-throughput lectin magnetic bead array-coupled tandem mass spectrometry for glycoprotein biomarker discovery.
Choi E, Loo D, Dennis JW, O'Leary CA, Hill MM.
Electrophoresis. 2011 Dec;32(24):3564-75. doi: 10.1002/elps.201100341.
PMID:22180208

The eggshell in the C. elegans oocyte-to-embryo transition.
Johnston WL, Dennis JW.
Genesis. 2012 Apr;50(4):333-49. doi: 10.1002/dvg.20823. Epub 2011 Dec 27. Review.
PMID:22083685

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M.
Nat Commun. 2011;2:334. doi: 10.1038/ncomms1333.
PMID:21629267 | PMCID:PMC3133923

Glycosylation, galectins and cellular signaling.
Boscher C, Dennis JW, Nabi IR.
Curr Opin Cell Biol. 2011 Aug;23(4):383-92. doi: 10.1016/j.ceb.2011.05.001. Epub 2011 May 26. Review.
PMID:21616652

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.
Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB.
Genes Dev. 2010 Dec 15;24(24):2784-99. doi: 10.1101/gad.1985910. Epub 2010 Nov 24.
PMID:21106670 | PMCID:PMC3003197

Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans.
Johnston WL, Krizus A, Dennis JW.
Curr Biol. 2010 Nov 9;20(21):1932-7. doi: 10.1016/j.cub.2010.09.059. Epub 2010 Oct 28.
PMID:20971008

Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia.
Shi Y, Tomic J, Wen F, Shaha S, Bahlo A, Harrison R, Dennis JW, Williams R, Gross BJ, Walker S, Zuccolo J, Deans JP, Hart GW, Spaner DE.
Leukemia. 2010 Sep;24(9):1588-98. doi: 10.1038/leu.2010.152. Epub 2010 Jul 29.
PMID:20668475 | PMCID:PMC4361888

Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Rosario CO, Ko MA, Haffani YZ, Gladdy RA, Paderova J, Pollett A, Squire JA, Dennis JW, Swallow CJ.
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6888-93. doi: 10.1073/pnas.0910941107. Epub 2010 Mar 26.
PMID:20348415 | PMCID:PMC2872425

Metabolism, cell surface organization, and disease.
Dennis JW, Nabi IR, Demetriou M.
Cell. 2009 Dec 24;139(7):1229-41. doi: 10.1016/j.cell.2009.12.008. Review.
PMID:20064370 | PMCID:PMC3065826

Adaptive regulation at the cell surface by N-glycosylation.
Dennis JW, Lau KS, Demetriou M, Nabi IR.
Traffic. 2009 Nov;10(11):1569-78. doi: 10.1111/j.1600-0854.2009.00981.x. Epub 2009 Sep 2. Review.
PMID:19761541

Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae.
Lajoie P, Kojic LD, Nim S, Li L, Dennis JW, Nabi IR.
J Cell Mol Med. 2009 Sep;13(9B):3218-25. doi: 10.1111/j.1582-4934.2009.00732.x. Epub 2009 Mar 6.
PMID:19438805 | PMCID:PMC4516479

Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane.
Lajoie P, Goetz JG, Dennis JW, Nabi IR.
J Cell Biol. 2009 May 4;185(3):381-5. doi: 10.1083/jcb.200811059. Epub 2009 Apr 27. Review.
PMID:19398762 | PMCID:PMC2700393

N-Glycans in cancer progression.
Lau KS, Dennis JW.
Glycobiology. 2008 Oct;18(10):750-60. doi: 10.1093/glycob/cwn071. Epub 2008 Aug 13. Review.
PMID:18701722

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD.
Cancer Res. 2008 Aug 15;68(16):6688-97. doi: 10.1158/0008-5472.CAN-07-6833. Erratum in: Cancer Res. 2008 Sep 15;68(18):7692.
PMID:18701493

Genome-scale identification of UDP-GlcNAc-dependent pathways.
Lau KS, Khan S, Dennis JW.
Proteomics. 2008 Aug;8(16):3294-302. doi: 10.1002/pmic.200800208.
PMID:18646010

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.
Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, Wrana JL, Dennis JW, Schimmer AD.
Apoptosis. 2008 Mar;13(3):413-22. doi: 10.1007/s10495-007-0175-4.
PMID:18181020

Complex N-glycan and metabolic control in tumor cells.
Mendelsohn R, Cheung P, Berger L, Partridge E, Lau K, Datti A, Pawling J, Dennis JW.
Cancer Res. 2007 Oct 15;67(20):9771-80.
PMID:17942907

Plasma membrane domain organization regulates EGFR signaling in tumor cells.
Lajoie P, Partridge EA, Guay G, Goetz JG, Pawling J, Lagana A, Joshi B, Dennis JW, Nabi IR.
J Cell Biol. 2007 Oct 22;179(2):341-56. Epub 2007 Oct 15.
PMID:17938246 | PMCID:PMC2064769

Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.
Martindill DM, Risebro CA, Smart N, Franco-Viseras Mdel M, Rosario CO, Swallow CJ, Dennis JW, Riley PR.
Nat Cell Biol. 2007 Oct;9(10):1131-41. Epub 2007 Sep 23.
PMID:17891141

Beta N-acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression-like phenotype in mice.
Soleimani L, Roder JC, Dennis JW, Lipina T.
Genes Brain Behav. 2008 Apr;7(3):334-43. Epub 2007 Sep 18.
PMID:17883406

Biological implications of SNPs in signal peptide domains of human proteins.
Jarjanazi H, Savas S, Pabalan N, Dennis JW, Ozcelik H.
Proteins. 2008 Feb 1;70(2):394-403.
PMID:17680692

Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.
Grigorian A, Lee SU, Tian W, Chen IJ, Gao G, Mendelsohn R, Dennis JW, Demetriou M.
J Biol Chem. 2007 Jul 6;282(27):20027-35. Epub 2007 May 8.
PMID:17488719

Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans.
Cheung P, Pawling J, Partridge EA, Sukhu B, Grynpas M, Dennis JW.
Glycobiology. 2007 Aug;17(8):828-37. Epub 2007 May 4.
PMID:17483135

Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.
Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW.
Cell. 2007 Apr 6;129(1):123-34.
PMID:17418791

Mgat5 and Pten interact to regulate cell growth and polarity.
Cheung P, Dennis JW.
Glycobiology. 2007 Jul;17(7):767-73. Epub 2007 Mar 30.
PMID:17400585

Cytokine sensitivity and N-glycan processing mutations.
Partridge EA, Cheung P, Dennis JW.
Methods Enzymol. 2006;417:3-11. Review.
PMID:17132493

The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo.
Johnston WL, Krizus A, Dennis JW.
BMC Biol. 2006 Oct 16;4:35.
PMID:17042944 | PMCID:PMC1635065

Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth.
Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL, Dennis JW.
Cancer Res. 2006 Apr 1;66(7):3558-66.
PMID:16585180

Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells.
Lagana A, Goetz JG, Cheung P, Raz A, Dennis JW, Nabi IR.
Mol Cell Biol. 2006 Apr;26(8):3181-93.
PMID:16581792 | PMCID:PMC1446937

Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain.
Inamori K, Mita S, Gu J, Mizuno-Horikawa Y, Miyoshi E, Dennis JW, Taniguchi N.
Biochim Biophys Acta. 2006 Apr;1760(4):678-84. Epub 2005 Dec 27.
PMID:16413118

Simple enzymatic means to neutralize DNA contamination in nucleic acid amplification.
Ashkenas J, Dennis JW, Ho CY.
Biotechniques. 2005 Jul;39(1):69-73.
PMID:16060371

Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.
Ko MA, Rosario CO, Hudson JW, Kulkarni S, Pollett A, Dennis JW, Swallow CJ.
Nat Genet. 2005 Aug;37(8):883-8. Epub 2005 Jul 17.
PMID:16025114

Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation.
Jia Z, Barbier L, Stuart H, Amraei M, Pelech S, Dennis JW, Metalnikov P, O'Donnell P, Nabi IR.
J Biol Chem. 2005 Aug 26;280(34):30564-73. Epub 2005 Jun 28.
PMID:15985431

Regulation of BMP-induced ectopic bone formation by Ahsg.
Rittenberg B, Partridge E, Baker G, Clokie C, Zohar R, Dennis JW, Tenenbaum HC.
J Orthop Res. 2005 May;23(3):653-62.
PMID:15885488

Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN.
Antivir Ther. 2005;10(2):263-75.
PMID:15865221

The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies.
Lajoie P, Guay G, Dennis JW, Nabi IR.
J Cell Sci. 2005 May 1;118(Pt 9):1991-2003. Epub 2005 Apr 19.
PMID:15840653

Sak/Plk4 and mitotic fidelity.
Swallow CJ, Ko MA, Siddiqui NU, Hudson JW, Dennis JW.
Oncogene. 2005 Jan 10;24(2):306-12. Review.
PMID:15640847

N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells.
Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, Li B.
J Immunol. 2004 Dec 15;173(12):7200-8.
PMID:15585841

Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.
Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, Granovsky M, Nabi IR, Wrana JL, Dennis JW.
Science. 2004 Oct 1;306(5693):120-4.
PMID:15459394

alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression.
Swallow CJ, Partridge EA, Macmillan JC, Tajirian T, DiGuglielmo GM, Hay K, Szweras M, Jahnen-Dechent W, Wrana JL, Redston M, Gallinger S, Dennis JW.
Cancer Res. 2004 Sep 15;64(18):6402-9.
PMID:15374947

Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study.
Loutfy MR, Blatt LM, Siminovitch KA, Ward S, Wolff B, Lho H, Pham DH, Deif H, LaMere EA, Chang M, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Dennis JW, Lai EK, Fish EN.
JAMA. 2003 Dec 24;290(24):3222-8.
PMID:14693875

STAT1 and STAT3 alpha/beta splice form activation predicts host responses in mouse hepatitis virus type 2 infection. J Med Virol 2003;69:306-312.
Levy G, Berger L, Dennis JW.
J Med Virol. 2003 Nov;71(3):474. No abstract available.
PMID:12966557

UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice.
Dennis JW, Pawling J, Cheung P, Partridge E, Demetriou M.
Biochim Biophys Acta. 2002 Dec 19;1573(3):414-22. Review.
PMID:12417426

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.
Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW, Sicheri F.
Nat Struct Biol. 2002 Oct;9(10):719-24.
PMID:12352953

The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells.
Warren CE, Krizus A, Roy PJ, Culotti JG, Dennis JW.
J Biol Chem. 2002 Jun 21;277(25):22829-38. Epub 2002 Apr 5.
PMID:11937505

alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling.
Szweras M, Liu D, Partridge EA, Pawling J, Sukhu B, Clokie C, Jahnen-Dechent W, Tenenbaum HC, Swallow CJ, Grynpas MD, Dennis JW.
J Biol Chem. 2002 May 31;277(22):19991-7. Epub 2002 Mar 18.
PMID:11901155

Genetic defects in N-glycosylation and cellular diversity in mammals.
Dennis JW, Warren CE, Granovsky M, Demetriou M.
Curr Opin Struct Biol. 2001 Oct;11(5):601-7. Review.
PMID:11785762

Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues.
Warren CE, Krizus A, Dennis JW.
Glycobiology. 2001 Nov;11(11):979-88.
PMID:11744632

Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer.
Macmillan JC, Hudson JW, Bull S, Dennis JW, Swallow CJ.
Ann Surg Oncol. 2001 Oct;8(9):729-40.
PMID:11597015

Quality control of resident operative experience: compliance with RRC criteria.
Veldenz HC, Dennis JW, Dovgan PS.
J Surg Res. 2001 Jun 15;98(2):81-4.
PMID:11397122

Late mitotic failure in mice lacking Sak, a polo-like kinase.
Hudson JW, Kozarova A, Cheung P, Macmillan JC, Swallow CJ, Cross JC, Dennis JW.
Curr Biol. 2001 Mar 20;11(6):441-6.
PMID:11301255

Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation.
Demetriou M, Granovsky M, Quaggin S, Dennis JW.
Nature. 2001 Feb 8;409(6821):733-9.
PMID:11217864

Regulation of human monocyte proMMP-9 production by fetuin, an endogenous TGF-beta antagonist.
Tajirian T, Dennis JW, Swallow CJ.
J Cell Physiol. 2000 Nov;185(2):174-83.
PMID:11025439

Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells.
Boehmelt G, Wakeham A, Elia A, Sasaki T, Plyte S, Potter J, Yang Y, Tsang E, Ruland J, Iscove NN, Dennis JW, Mak TW.
EMBO J. 2000 Oct 2;19(19):5092-104.
PMID:11013212 | PMCID:PMC302091

A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research.
Donovan RS, Datti A, Baek MG, Wu Q, Sas IJ, Korczak B, Berger EG, Roy R, Dennis JW.
Glycoconj J. 1999 Oct;16(10):607-15.
PMID:10972139

Minimal catalytic domain of N-acetylglucosaminyltransferase V.
Korczak B, Le T, Elowe S, Datti A, Dennis JW.
Glycobiology. 2000 Jun;10(6):595-9.
PMID:10814701

A homogeneous cell-based assay to identify N-linked carbohydrate processing inhibitors.
Datti A, Donovan RS, Korczak B, Dennis JW.
Anal Biochem. 2000 Apr 10;280(1):137-42.
PMID:10805531

Suppression of tumor growth and metastasis in Mgat5-deficient mice.
Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW.
Nat Med. 2000 Mar;6(3):306-12.
PMID:10700233

Biogenesis of multilamellar bodies via autophagy.
Hariri M, Millane G, Guimond MP, Guay G, Dennis JW, Nabi IR.
Mol Biol Cell. 2000 Jan;11(1):255-68.
PMID:10637306 | PMCID:PMC14772

Sak kinase gene structure and transcriptional regulation.
Hudson JW, Chen L, Fode C, Binkert C, Dennis JW.
Gene. 2000 Jan 4;241(1):65-73.
PMID:10607900

Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice.
Koya D, Dennis JW, Warren CE, Takahara N, Schoen FJ, Nishio Y, Nakajima T, Lipes MA, King GL.
FASEB J. 1999 Dec;13(15):2329-37.
PMID:10593880

Glycoprotein glycosylation and cancer progression.
Dennis JW, Granovsky M, Warren CE.
Biochim Biophys Acta. 1999 Dec 6;1473(1):21-34. Review.
PMID:10580127

Overexpression of the alpha2,6-sialyltransferase, ST6Gal I, in a low metastatic variant of a murine lymphoblastoid cell line is associated with appearance of a unique ST6Gal I mRNA.
Lo NW, Dennis JW, Lau JT.
Biochem Biophys Res Commun. 1999 Nov 2;264(3):619-21.
PMID:10543981

Regulation of osteogenesis by fetuin.
Binkert C, Demetriou M, Sukhu B, Szweras M, Tenenbaum HC, Dennis JW.
J Biol Chem. 1999 Oct 1;274(40):28514-20.
PMID:10497215

Protein glycosylation in development and disease.
Dennis JW, Granovsky M, Warren CE.
Bioessays. 1999 May;21(5):412-21. Review.
PMID:10376012

New approaches in the binding of DNA for clinical applications.
Levison PR, Dennis JW, Jones KD, Philpott RW, Taylor SL, Grimm V.
Clin Chem. 1998 Sep;44(9):2060-1. No abstract available.
PMID:9733012

The extent of polylactosamine glycosylation of MDCK LAMP-2 is determined by its Golgi residence time.
Nabi IR, Dennis JW.
Glycobiology. 1998 Sep;8(9):947-53.
PMID:9675228

Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies.
Goss PE, Reid CL, Bailey D, Dennis JW.
Clin Cancer Res. 1997 Jul;3(7):1077-86.
PMID:9815786

Modification of CD43 and other lymphocyte O-glycoproteins by core 2 N-acetylglucosaminyltransferase.
Barran P, Fellinger W, Warren CE, Dennis JW, Ziltener HJ.
Glycobiology. 1997 Feb;7(1):129-36.
PMID:9061371

Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation.
Fode C, Binkert C, Dennis JW.
Mol Cell Biol. 1996 Sep;16(9):4665-72.
PMID:8756623 | PMCID:PMC231466

Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist.
Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW.
J Biol Chem. 1996 May 31;271(22):12755-61.
PMID:8662721

GlcNAc-transferase V and core 2 GlcNAc-transferase expression in the developing mouse embryo.
Granovsky M, Fode C, Warren CE, Campbell RM, Marth JD, Pierce M, Fregien N, Dennis JW.
Glycobiology. 1995 Dec;5(8):797-806.
PMID:8720078

Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.
Nishio Y, Warren CE, Buczek-Thomas JA, Rulfs J, Koya D, Aiello LP, Feener EP, Miller TB Jr, Dennis JW, King GL.
J Clin Invest. 1995 Oct;96(4):1759-67.
PMID:7560067 | PMCID:PMC366652

Inhibitors of carbohydrate processing: A new class of anticancer agents.
Goss PE, Baker MA, Carver JP, Dennis JW.
Clin Cancer Res. 1995 Sep;1(9):935-44. Review.
PMID:9816064

Complex asparagine-linked oligosaccharides in Mgat1-null embryos.
Campbell RM, Metzler M, Granovsky M, Dennis JW, Marth JD.
Glycobiology. 1995 Jul;5(5):535-43.
PMID:8563140

Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V.
Demetriou M, Nabi IR, Coppolino M, Dedhar S, Dennis JW.
J Cell Biol. 1995 Jul;130(2):383-92.
PMID:7615638 | PMCID:PMC2199932

Sialylation and malignant potential in tumour cell glycosylation mutants.
Takano R, Muchmore E, Dennis JW.
Glycobiology. 1994 Oct;4(5):665-74.
PMID:7881181

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.
Fode C, Motro B, Yousefi S, Heffernan M, Dennis JW.
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6388-92.
PMID:8022793 | PMCID:PMC44207

A phase I study of swainsonine in patients with advanced malignancies.
Goss PE, Baptiste J, Fernandes B, Baker M, Dennis JW.
Cancer Res. 1994 Mar 15;54(6):1450-7.
PMID:8137247

Measuring swainsonine in serum of cancer patients: phase I clinical trial.
Baptista JA, Goss P, Nghiem M, Krepinsky JJ, Baker M, Dennis JW.
Clin Chem. 1994 Mar;40(3):426-30.
PMID:8131279

Branching N-linked oligosaccharides in breast cancer.
Korczak B, Goss P, Fernandez B, Baker M, Dennis JW.
Adv Exp Med Biol. 1994;353:95-104. Review.
PMID:7985545

Reassessing the role of arteriograms in the management of posterior knee dislocations.
Dennis JW, Jagger C, Butcher JL, Menawat SS, Neel M, Frykberg ER.
J Trauma. 1993 Nov;35(5):692-5; discussion 695-7.
PMID:8230331

Carbonoyloxy analogs of the anti-metastatic drug swainsonine. Activation in tumor cells by esterases.
Dennis JW, White SL, Freer AM, Dime D.
Biochem Pharmacol. 1993 Oct 19;46(8):1459-66.
PMID:8240396

Antisense and sense cDNA expression cloning using autonomously replicating vectors and toxic lectin selection.
Cummings L, Warren CE, Granovsky M, Dennis JW.
Biochem Biophys Res Commun. 1993 Sep 15;195(2):814-22.
PMID:8373417

Core 2 GlcNAc-transferase and polylactosamine expression in O-glycans.
Dennis JW.
Glycobiology. 1993 Apr;3(2):91-3. No abstract available.
PMID:8490245

Regulation of UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1-6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc) in Chinese hamster ovary cells.
Datti A, Dennis JW.
J Biol Chem. 1993 Mar 15;268(8):5409-16.
PMID:8383671

Inhibition of N-linked oligosaccharide processing in tumor cells is associated with enhanced tissue inhibitor of metalloproteinases (TIMP) gene expression.
Korczak B, Dennis JW.
Int J Cancer. 1993 Feb 20;53(4):634-9.
PMID:8436437

Branching beta 1-6N-acetylglucosaminetransferases and polylactosamine expression in mouse F9 teratocarcinoma cells and differentiated counterparts.
Heffernan M, Lotan R, Amos B, Palcic M, Takano R, Dennis JW.
J Biol Chem. 1993 Jan 15;268(2):1242-51.
PMID:8419327

Defective expression of CD23 and autocrine growth-stimulation in Epstein-Barr virus (EBV)-transformed B cells from patients with Wiskott-Aldrich syndrome (WAS).
Simon HU, Higgins EA, Demetriou M, Datti A, Siminovitch KA, Dennis JW.
Clin Exp Immunol. 1993 Jan;91(1):43-9.
PMID:8380367 | PMCID:PMC1554645

A coupled assay for UDP-GlcNAc:Gal beta 1-3GalNAc-R beta 1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc).
Datti A, Orlacchio A, Siminovitch KA, Dennis JW.
Anal Biochem. 1992 Nov 1;206(2):262-6.
PMID:1443596

N-linked oligosaccharide processing and tumor cell biology.
Dennis JW.
Semin Cancer Biol. 1991 Dec;2(6):411-20. Review.
PMID:1810469

Tn antigen and UDP-Gal:GalNAc alpha-R beta 1-3Galactosyltransferase expression in human breast carcinoma.
Zhuang D, Yousefi S, Dennis JW.
Cancer Biochem Biophys. 1991 Nov;12(3):185-98.
PMID:1844911

CMP-N-acetylneuraminic acid hydroxylase activity determines the wheat germ agglutinin-binding phenotype in two mutants of the lymphoma cell line MDAY-D2.
Shaw L, Yousefi S, Dennis JW, Schauer R.
Glycoconj J. 1991 Oct;8(5):434-41.
PMID:1841685

Characterization of O-linked oligosaccharide biosynthesis in cultured cells using paranitrophenyl alpha-D-GalNAc as an acceptor.
Zhuang D, Grey A, Harris-Brandts M, Higgins E, Kashem MA, Dennis JW.
Glycobiology. 1991 Sep;1(4):425-33.
PMID:1820202

Autocrine and paracrine regulation of tissue inhibitor of metalloproteinases, transin, and urokinase gene expression in metastatic and nonmetastatic mammary carcinoma cells.
Korczak B, Kerbel RS, Dennis JW.
Cell Growth Differ. 1991 Jul;2(7):335-41.
PMID:1782152

Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome.
Higgins EA, Siminovitch KA, Zhuang DL, Brockhausen I, Dennis JW.
J Biol Chem. 1991 Apr 5;266(10):6280-90.
PMID:2007580

N-linked oligosaccharide processing and autocrine stimulation of tumor cell proliferation.
VanderElst I, Dennis JW.
Exp Cell Res. 1991 Feb;192(2):612-21.
PMID:1899075

Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis.
Yousefi S, Higgins E, Daoling Z, Pollex-Krüger A, Hindsgaul O, Dennis JW.
J Biol Chem. 1991 Jan 25;266(3):1772-82.
PMID:1824844

Beta 1-6 branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasia.
Fernandes B, Sagman U, Auger M, Demetrio M, Dennis JW.
Cancer Res. 1991 Jan 15;51(2):718-23.
PMID:1985789

Polyoma and hamster papovavirus large T antigen-mediated replication of expression shuttle vectors in Chinese hamster ovary cells.
Heffernan M, Dennis JW.
Nucleic Acids Res. 1991 Jan 11;19(1):85-92.
PMID:2011514 | PMCID:PMC333537

Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization.
Cornil I, Kerbel RS, Dennis JW.
J Cell Biol. 1990 Aug;111(2):773-81.
PMID:2116422 | PMCID:PMC2116217

Basement membrane invasion by first trimester human trophoblast: requirement for branched complex-type Asn-linked oligosaccharides.
Yagel S, Kerbel R, Lala P, Eldar-Gera T, Dennis JW.
Clin Exp Metastasis. 1990 Jul-Aug;8(4):305-17.
PMID:2112436

Growth inhibition of human melanoma tumor xenografts in athymic nude mice by swainsonine.
Dennis JW, Koch K, Yousefi S, VanderElst I.
Cancer Res. 1990 Mar 15;50(6):1867-72.
PMID:2106389

Asparagine-linked oligosaccharides associated with metastatic cancer.
Dennis JW, Laferté S, Yagel S, Breitman ML.
Cancer Cells. 1989 Nov;1(3):87-92. Review.
PMID:2701653

Molecular characterization of P2B/LAMP-1, a major protein target of a metastasis-associated oligosaccharide structure.
Heffernan M, Yousefi S, Dennis JW.
Cancer Res. 1989 Nov 1;49(21):6077-84.
PMID:2676155

Evidence that beta 1-6 branched Asn-linked oligosaccharides on metastatic tumor cells facilitate invasion of basement membranes.
Yagel S, Feinmesser R, Waghorne C, Lala PK, Breitman ML, Dennis JW.
Int J Cancer. 1989 Oct 15;44(4):685-90.
PMID:2507455

Altered expression of leucocyte sialoglycoprotein in Wiskott-Aldrich syndrome is associated with a specific defect in O-glycosylation.
Greer WL, Higgins E, Sutherland DR, Novogrodsky A, Brockhausen I, Peacocke M, Rubin LA, Baker M, Dennis JW, Siminovitch KA.
Biochem Cell Biol. 1989 Sep;67(9):503-9.
PMID:2803729

Plasma polymerized tetrafluoroethylene/polyethylene terephthalate vascular prostheses.
Greisler HP, Dennis JW, Schwarcz TH, Klosak JJ, Ellinger J, Kim DU.
Arch Surg. 1989 Aug;124(8):967-72. Erratum in: Arch Surg 1990 Jan;125(1):96.
PMID:2527022

Inhibition of human HT29 colon carcinoma growth in vitro and in vivo by swainsonine and human interferon-alpha 2.
Dennis JW, Koch K, Beckner D.
J Natl Cancer Inst. 1989 Jul 5;81(13):1028-33.
PMID:2499693

Oncogenes conferring metastatic potential induce increased branching of Asn-linked oligosaccharides in rat2 fibroblasts.
Dennis JW, Kosh K, Bryce DM, Breitman ML.
Oncogene. 1989 Jul;4(7):853-60.
PMID:2666906

Purification of two glycoproteins expressing beta 1-6 branched Asn-linked oligosaccharides from metastatic tumour cells.
Laferte S, Dennis JW.
Biochem J. 1989 Apr 15;259(2):569-76.
PMID:2719668 | PMCID:PMC1138546

Oncodevelopmental expression of--GlcNAc beta 1-6Man alpha 1-6Man beta 1--branched asparagine-linked oligosaccharides in murine tissues and human breast carcinomas.
Dennis JW, Laferté S.
Cancer Res. 1989 Feb 15;49(4):945-50.
PMID:2521456

Asparagine-linked oligosaccharides in malignant tumour growth.
Dennis JW, Laferté S, Vanderelst I.
Biochem Soc Trans. 1989 Feb;17(1):29-31.
PMID:2714513

Glycosylation-dependent collagen-binding activities of two membrane glycoproteins in MDAY-D2 tumor cells.
Laferté S, Dennis JW.
Cancer Res. 1988 Sep 1;48(17):4743-8.
PMID:3409215

Isolation and characterization of spontaneous wheat germ agglutinin-resistant human melanoma mutants displaying remarkably different metastatic profiles in nude mice.
Ishikawa M, Dennis JW, Man S, Kerbel RS.
Cancer Res. 1988 Feb 1;48(3):665-70.
PMID:3335029

Asn-linked oligosaccharide processing and malignant potential.
Dennis JW.
Cancer Surv. 1988;7(4):573-95. Review.
PMID:3072067

Double restriction in NK cell recognition is linked to transmethylation and can be triggered by asparagine-linked oligosaccharides on tumor cells.
Kiyohara T, Dennis JW, Roder JC.
Cell Immunol. 1987 May;106(2):223-33.
PMID:3568148

Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis.
Dennis JW, Laferté S, Waghorne C, Breitman ML, Kerbel RS.
Science. 1987 May 1;236(4801):582-5.
PMID:2953071

Glycosphingolipids of lectin-resistant mutants of the highly metastatic mouse tumor cell line, MDAY-D2.
Laferté S, Fukuda MN, Fukuda M, Dell A, Dennis JW.
Cancer Res. 1987 Jan 1;47(1):150-9.
PMID:3791202

Tumor cell surface carbohydrate and the metastatic phenotype.
Dennis JW, Laferte S.
Cancer Metastasis Rev. 1987;5(3):185-204. Review.
PMID:3549035

Asn-linked oligosaccharides in lectin-resistant tumor-cell mutants with varying metastatic potential.
Dennis JW, Laferté S, Fukuda M, Dell A, Carver JP.
Eur J Biochem. 1986 Dec 1;161(2):359-73.
PMID:3780748

Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis.
Dennis JW.
Cancer Res. 1986 Oct;46(10):5131-6.
PMID:3093060

Co-reversion of a lectin-resistant mutation and non-metastatic phenotype in murine tumor cells.
Dennis JW, Laferte S.
Int J Cancer. 1986 Sep 15;38(3):445-50.
PMID:3744595

Different metastatic phenotypes in two genetic classes of wheat germ agglutinin-resistant tumor cell mutants.
Dennis JW.
Cancer Res. 1986 Sep;46(9):4594-600.
PMID:3755374

Recognition of asparagine-linked oligosaccharides on murine tumor cells by natural killer cells.
Dennis JW, Laferté S.
Cancer Res. 1985 Dec;45(12 Pt 1):6034-40.
PMID:4063962

An exoglycosidase-sensitive triggering site on NK cells which is coupled to transmethylation of membrane phospholipids.
Kiyohara T, Dennis JW, Boegman RJ, Roder JC.
J Immunol. 1985 Jul;135(1):659-64.
PMID:3923114

Partial reversion of the metastatic phenotype in a wheat germ agglutinin-resistant mutant of the murine tumor cell line MDAY-D2 selected with Bandeiraea simplicifolia seed lectin.
Dennis JW.
J Natl Cancer Inst. 1985 May;74(5):1111-20.
PMID:3858579

Adoptive immune therapy in mice bearing poorly immunogenic metastases, using T lymphocytes stimulated in vitro against highly immunogenic mutant sublines.
Dennis JW, Laferté S, Man MS, Elliott BE, Kerbel RS.
Int J Cancer. 1984 Nov 15;34(5):709-16.
PMID:6437992

Identification of asparagine-linked oligosaccharides involved in tumor cell adhesion to laminin and type IV collagen.
Dennis JW, Waller CA, Schirrmacher V.
J Cell Biol. 1984 Oct;99(4 Pt 1):1416-23.
PMID:6237114 | PMCID:PMC2113307

Asparagine-linked oligosaccharides in murine tumor cells: comparison of a WGA-resistant (WGAr) nonmetastatic mutant and a related WGA-sensitive (WGAs) metastatic line.
Dennis JW, Carver JP, Schachter H.
J Cell Biol. 1984 Sep;99(3):1034-44.
PMID:6547960 | PMCID:PMC2113381

Genotypic and phenotypic evolution of a murine tumor during its progression in vivo toward metastasis.
Lagarde AE, Donaghue TP, Dennis JW, Kerbel RS.
J Natl Cancer Inst. 1983 Jul;71(1):183-91.
PMID:6575202

Spontaneous fusion in vivo between normal host and tumor cells: possible contribution to tumor progression and metastasis studied with a lectin-resistant mutant tumor.
Kerbel RS, Lagarde AE, Dennis JW, Donaghue TP.
Mol Cell Biol. 1983 Apr;3(4):523-38.
PMID:6687920 | PMCID:PMC368568

Relevance of spontaneous in vivo tumor-host cell fusion to tumor progression and metastasis evaluated using a series of lectin-resistant mutant tumor sublines.
Kerbel RS, Lagarde AE, Dennis JW, Nestel FP, Donaghue TP, Siminovitch L, Fulchignoni-Lataud MC.
Symp Fundam Cancer Res. 1983;36:47-79. Review. No abstract available.
PMID:6382520

Phenotypic and genotypic differences between high- and low-metastatic related tumor lines and the problem of tumor progression and variant generation.
Schirrmacher V, Dzarlieva R, Altevogt P, Fogel M, Waller CA, Dennis JW, Springer GF, Vlodavsky I, Kramer M, Cheingsong-Popov R.
Symp Fundam Cancer Res. 1983;36:81-99.
PMID:6332358

Comparative analysis of cell surface markers on murine NK cells and CTL target-effector conjugates.
Beaumont TJ, Roder JC, Elliott BE, Kerbel RS, Dennis JW, Kasai M, Okumura K.
Scand J Immunol. 1982 Aug;16(2):123-33.
PMID:6127796

A new method for the preparation of solid-phase immunoadsorbents.
Phillips ER, Dennis JW, Elliott BE, Kerbel RS.
Anal Biochem. 1982 Mar 15;121(1):83-90. No abstract available.
PMID:7091688

Tumor progression in metastasis: an experimental approach using lectin resistant tumor variants.
Kerbel RS, Dennis JW, Largarde AE, Frost P.
Cancer Metastasis Rev. 1982;1(2):99-140. Review.
PMID:6764377

EA rosettes using IgG monoclonal antibody-coated erythrocytes: degree of rosette formation correlates with the amount of antibody on the erythrocytes.
Dennis JW, Kerbel RS, Roder JC.
Scand J Immunol. 1981 Nov;14(5):537-44.
PMID:7336173

Demonstration of a correlation between tumor cell H-2 antigen content, immunogenicity, and tumorigenicity using lectin-resistant tumor variants.
Dennis JW, Donaghue TP, Carlow DA, Kerbel RS.
Cancer Res. 1981 Oct;41(10):4010-9. No abstract available.
PMID:6974593

Characterization of a deficiency in fucose metabolism in lectin-resistant variants of a murine tumor showing altered tumorigenic and metastatic capacities in vivo.
Dennis JW, Kerbel RS.
Cancer Res. 1981 Jan;41(1):98-104. No abstract available.
PMID:7448779

An examination of tumor antigen loss in spontaneous metastases.
Dennis JW, Donaghue TP, Kerbel RS.
Invasion Metastasis. 1981;1(2):111-25.
PMID:6985358

Membrane-associated alterations detected in poorly tumorigenic lectin-resistant variant sublines of a highly malignant and metastatic murine tumor.
Dennis JW, Donaghue TP, Kerbel RS.
J Natl Cancer Inst. 1981 Jan;66(1):129-39.
PMID:6935454

Are there Fc receptors on non-lymphoreticular tumor cells?
Kerbel RS, Dennis JW.
Immunol Today. 1980 Sep;1(3):69-72. doi: 10.1016/0167-5699(80)90024-9. Epub 2004 Aug 25.
PMID:25289766

 

  

  
  
    
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